Elicio Therapeutics Announces Upcoming Presentations at the American Association for Cancer Research (AACR) Annual Meeting

BOSTON, March 06, 2024 (GLOBE NEWSWIRE) -- Elicio Therapeutics, Inc. (Nasdaq: ELTX, “Elicio Therapeutics” or “Elicio”), a clinical-stage biotechnology company developing a pipeline of novel immunotherapies for the treatment of cancer, today announced three upcoming poster presentations at the American Association for Cancer Research (“AACR”) Annual Meeting taking place from April 5-10, 2024, in San Diego, California. The presentations will highlight data on Elicio’s therapeutic cancer vaccine candidates, ELI-002, ELI-007 and ELI-008, built using Elicio’s Amphiphile (“AMP”) technology, which harnesses the power of the lymph nodes to generate and activate T cells to target solid tumors.

Presentation Details

Presentation Title: Durable immunogenicity of ELI-002 2P in AMPLIFY-201: Lymph node targeted mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer
Session Title: First-in-Human Phase I Clinical Trials 1
Session Date and Time: Monday, April 8, 2024, 1:30 PM - 5:00 PM PT
Location: Poster Section 48
Poster Board Number: 15
Abstract Presentation Number: CT107

Presentation Title: AMP-peptide vaccination against multiple p53 mutant epitopes promotes lymph node delivery to generate potent, functional T cell immunity
Session Title: Vaccines, Antigens, and Antigen Presentation 1
Session Date and Time: Tuesday, April 9, 2024, 9:00 AM - 12:30 PM PT
Location: Poster Section 5
Poster Board Number: 10
Published Abstract Number: 4099

Presentation Title: AMP-peptide vaccination against mutant BRAF epitopes promotes lymph node delivery to generate potent, functional T cell immunity
Session Title: Vaccines, Antigens, and Antigen Presentation 1
Session Date and Time: Tuesday, April 9, 2024, 9:00 AM - 12:30 PM PT
Location: Poster Section 5
Poster Board Number: 11
Published Abstract Number: 4100

About ELI-002
ELI-002 is a structurally novel investigational AMP immunotherapy targeting mutant Kristen rat sarcoma (“KRAS”)-driven cancers. KRAS mutations are among the most prevalent human cancers. The seven KRAS driver mutations targeted by the ELI-002 7P formulation are present in 25% of all solid tumors. In particular, 93% of pancreatic ductal adenocarcinoma and 52% of colorectal cancers, those most prevalent in the AMPLIFY-201 study, are positive for KRAS mutations. In addition, 27% of non-small cell lung cancers are positive for KRAS mutations. ELI-002 is comprised of AMP-modified mutant KRAS (“mKRAS”) peptide antigens and an AMP-modified CpG adjuvant available as an off-the-shelf subcutaneous administration. The AMP mKRAS peptide antigen and AMP CpG optimize the natural ability of the lymph nodes to educate, activate and amplify cancer-specific T cells enhancing a robust immune response.