ESPERITE (Euronext ESP) pioneers first treatment worldwide of Cerebral Palsy using two types of stem cells

CryoSave, part of ESPERITE, is the only private cord blood bank sponsoring a GCP clinical trial according to GMP-ATMP international guidelines

 

CryoSave leads and sponsors a multicentre clinical trial following GCP-ICH standards, for investigation of new treatment of Cerebral Palsy using dual infusion of two types of stem cells derived from umbilical cord blood and cord tissue processed by CryoSave

 

Geneva, Switzerland - 23 February 2015

 

The clinical trial aims to demonstrate safety and preliminary efficacy of sequential intravenous infusion of the ex vivo expanded mesenchymal stem cells (MSC) derived from cord tissue and the cord blood stem cells. The study will use, for the first time in clinical research, autologous MSC

derived from cryopreserved cord tissue. The clinical trial, sponsored by CryoSave, will be performed in collaboration with Professor Manuel Ramírez Orellana, the Principal Investigator, and Professor Luis Madero, the Clinical Supervisor from the University Hospital Niño Jesus in Madrid, Spain.

 

Cerebral Palsy is a devastating disease diagnosed in 1 per 326 children according to CDC, with no available treatment. 17 Million people worldwide live affected by cerebral Palsy (CPIRF). 26 Billion USD are spent every year to accommodate the life of these patients in the US (WHO).

 

A number of clinical case studies and clinical trials are ongoing using stem cells derived from cord blood or from cord tissue, demonstrating safety and efficacy in treatment of Cerebral Palsy. The stem cells of perinatal origin demonstrated high immune-modulatory and anti-inflammatory activity in vitro and in vivo, and strong trophic effect stimulating brain tissue regeneration. Patient's followup results will be compared with the same patient's MSC transcriptome, secretome and epigenome profile in vitro during the clinical trials.

 

Professor Luis Madero, the Clinical Supervisor from the University Hospital Niño Jesus in Madrid, Spain: "The launch of this clinical study in collaboration with the ESPERITE team gives great hope to me and the professors dedicated to treat terrible diseases through hematopoietic and mesenchymal stem cells".