Cognition Therapeutics Releases New Episode of “Conversations” Podcast

Protecting the Synapse from Amyloid Toxicity in Alzheimer's Disease

PURCHASE, N.Y., May 21, 2024 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (the “Company” or “Cognition”) (NASDAQ: CGTX), a clinical stage company developing drugs that treat neurodegenerative disorders, has released its eighth Conversations video podcast episode: “Protecting the Synapse from Amyloid Toxicity in Alzheimer's Disease.” This episode reviews how beta amyloid (Aβ) oligomers cause synaptic dysfunction, which is correlated with cognitive decline.

This conversation features a discussion of newly published research showing that Aβ oligomers bind to synapses in brain tissue of Alzheimer’s patients and how CT1812 acts to reverse their binding and reduce synaptotoxicity. Additionally, the panelists discuss using quantitative electroencephalography (EEG) as a real-time biomarker of synaptic function. In the Phase 2 ‘SEQUEL’ study of CT1812 in mild-to-moderate Alzheimer’s disease, four weeks of treatment was associated with trends to improvement in synaptic function and brain connectivity. Finally, Dr. Hamby summarized results of proteomic analysis demonstrating the impact of CT1812 treatment on proteins and pathways altered in Alzheimer’s disease, namely, synapse, amyloid beta processing and neuroinflammation.

Anthony Caggiano, M.D., Ph.D. CMO and head of R&D for Cognition Therapeutics moderates the discussion joined by VP of research, Mary Hamby, Ph.D. and two leading experts:

• Everard (Jort) Vijverberg, MD, PhD, Staff Neurologist and CNS Trial Specialist at the Amsterdam Alzheimer Center at Amsterdam Neuroscience
• Tara Spires Jones, DPhil, Personal Chair of Neurodegeneration and Deputy Director of the University of Edinburgh’s Centre for Discovery Brain Sciences

Listen to episode eight, “Protecting the Synapse from Amyloid Toxicity in Alzheimer's Disease” on the Conversations tab of the Cognition website.

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About Cognition Therapeutics, Inc.
Cognition Therapeutics, Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of innovative, small molecule therapeutics targeting age-related degenerative disorders of the central nervous system and retina. We are currently investigating our lead candidate CT1812 in clinical programs in Alzheimer’s disease, dementia with Lewy bodies (DLB) and dry age-related macular degeneration (dry AMD). We believe CT1812 and our pipeline of σ-2 receptor modulators can regulate pathways that are impaired in these diseases. We believe that targeting the σ-2 receptor with CT1812 represents a mechanism functionally distinct from other current approaches in clinical development for the treatment of degenerative diseases. More about Cognition Therapeutics and its pipeline can be found at https://cogrx.com.