Consolidated interim report 1 January – 31 March 2024

Consolidated interim report 1 January – 31 March 2024

Company announcement no. 17

Date: 16 May 2024

Key points from Q1-24 report (period 1 January - 31 March 2024)

On 16 May 2024, the Board of Directors and the Executive Management of Pharma Equity Group A/S (“PEG”, “the Company” or “the Group”) considered and approved the interim report of the Group for the period 1 January – 31 March 2024 ("Q1 2024 Report"). The report has not been audited or reviewed.

Clinical results

Shortly after the end of Q1, the Company's subsidiary, Reponex Pharmaceuticals A/S (Reponex), was able to report very positive final results from Reponex’ clinical phase 2 proof-of-concept trial of the drug candidate RNX-051, the MEFO study, based on the high-level summary received from Reponex’ clinical site. Reference is made to company announcement no. 11 from 15 April 2024.

Reponex' MEFO study is concerned with the treatment of patients with right-sided colon cancer and right-sided colon polyps/adenomas (precancerous cursors) with drug candidate RNX-051. Reponex’ clinical collaborators who conducted the study reported that, based on the results of the MEFO study, there appears to be a clear way forward to determine whether treatment with RNX-051 as a single and even repeated dose in patients with intestinal adenomas will lead to the prevention of adenomas.

Products and patents

On 22 January 2024, the Company announced in Company Announcement No. 2 that the Company's subsidiary, Reponex Pharmaceuticals A/S (Reponex) had announced that the European Patent Office (EPO) had approved EP patent application no. 3740286 which includes Reponex' innovative treatment method. The patent deals with drug compositions for the elimination of bacterial promoters of colorectal cancer by intraluminal application (RNX-051). The treatment method focuses on fighting the bacterial layer, also known as biofilm, which protects cancerous tumors in the colon or rectum. By defeating this protective barrier, the treatment seeks to make the cancer cells more susceptible to the body's own immune system.

On 5 March 2024, the Company announced in Company Announcement No. 6 that the Company's subsidiary, Reponex Pharmaceuticals A/S (Reponex) had announced that the European Patent Office (EPO) had approved EP patent application No. 3145533 for Reponex' Wound Healing Drug (RNX-022). The treatment method consists of topical application of a hydrogel containing granulocyte macrophage colony stimulating factor (GM-CSF), sucralfate, and hyaluronan to accelerate wound healing. The combination helps stimulate the proliferation of cells related to the healing process and tissue regeneration.