Skye Bioscience Highlights Novel Synthetic Cannabinoid-based Library Capable of Modulating the Endocannabinoid System to Treat Ocular Diseases at ARVO 2024 Annual Meeting

Poster presentation details screening approach allowing selection of candidate molecules applicable to dry eye disease and chronic ocular pain, with potential to identify therapeutic candidates with novel mechanisms of action for other ocular pathologies

SAN DIEGO, May 10, 2024 (GLOBE NEWSWIRE) -- Skye Bioscience, Inc. (Nasdaq: SKYE) (“Skye”), a clinical-stage biotechnology company focused on the discovery, development and commercialization of novel classes of therapeutic drugs that modulate the endocannabinoid system (ECS), today announced that it presented new data in a poster titled “Development and screening of a novel library of synthetic endocannabinoid agonists and inhibitors to advance a potential therapy to treat dry eye disease and chronic ocular pain” on May 9th at the ARVO (Association of Research in Vision and Ophthalmology) 2024 Annual Meeting.

“The endocannabinoid system offers unique opportunities to address unmet medical needs with new mechanisms of action. At ARVO we showcased Skye’s development and screening of a novel library of synthetic agonists and inhibitors that could potentially fulfill some of these opportunities,” said Punit Dhillon, Chief Executive Officer and Chairman of Skye.

Key highlights

1. Presented biological ECS screening program focused on pathways relevant to dry eye disease (DED) and chronic ocular pain
2. Three synthetic cannabinoid-based compounds relevant to DED and chronic ocular pain have been identified for further pharmaceutical development
3. Conclusion: a unique screening approach has the potential to provide a new class of therapeutics with novel mechanisms of action for the treatment of diverse ocular pathologies.
   

Chris Twitty, PhD, Chief Scientific Officer of Skye, added: “Skye’s strategy is to develop advanced pharmaceutical drugs capable of modulating the endocannabinoid system to positively impact ocular pathologies. The study’s evaluation of a novel synthetic cannabinoid-based library with biologically relevant cell types, targets, and pathways enabled the selection of candidate molecules applicable to DED and chronic ocular pain. Ultimately, we selected cannabinerol and two non-electrophilic indolic adducts of cannabidiolquinone and cannabigeroquinone that warrant further interrogation and pharmaceutical development.”