Chemomab Reports New Peer-Reviewed Publication Reinforcing the Clinical Association of Its CCL24 Target with Disease Severity and Mortality in Patients with Systemic Sclerosis

—Longitudinal Study of a 200+ Real-World Patient Cohort Further Validates CCL24 as a Novel Target for Systemic Sclerosis (SSc), Showing that It is Associated with Disease Severity Across the Fibrotic and Vascular Manifestations of SSc—

TEL AVIV, Israel, April 18, 2024 (GLOBE NEWSWIRE) -- Chemomab Therapeutics Ltd. (Nasdaq: CMMB), (Chemomab), a clinical stage biotechnology company developing innovative therapeutics to treat rare fibro-inflammatory diseases with high unmet need, today announced the publication of a new study that further confirms the key role of its novel soluble protein target CCL24 in systemic sclerosis (SSc). The study, “Serum CCL24 as a Biomarker of Fibrotic and Vascular Disease Severity in Systemic Sclerosis,” was published in the current edition of the journal Arthritis Care and Research.¹

“This important new longitudinal study in a large cohort of patients with SSc further confirms the extensive body of preclinical evidence we have generated showing that CCL24 is a key driver of the skin, lung and vascular complications in this terrible condition that lacks disease-modifying therapies,” said Adi Mor, PhD, a co-author of the publication and co-founder, CEO and CSO of Chemomab. “These results also reinforce our belief, based on multiple preclinical and patient sample studies, that our novel CCL24-neutralizing antibody CM-101 has substantial potential as a treatment for SSc. Our SSc program is Phase 2-ready with an open US IND, with possible initiation of patient enrollment after the topline readout from our Phase 2 trial in primary sclerosing cholangitis that is expected in the next few months.”

The longitudinal study was conducted by prominent SSc researchers at the University of Leeds in the UK and included more than 200 patients. It explored the relationship between serum CCL24 levels and SSc severity and prognosis. One in four patients in a real-life SSc population was found to have a high CCL24 serum concentration, despite standard of care treatment with immunosuppressive therapy. The analysis found that higher CCL24 levels were linked to critical clinical variables associated with the most severe forms of SSc. They include severity of skin fibrosis and calcinosis, presence of interstitial lung disease (ILD), lung microvascular impairment, and a history of digital ulcers and synovitis.