Angle PLC Announces Parsortix HER2 Assay Showcased at AACR 2024

PARSORTIX HER2 ASSAY SHOWCASED AT PRESTIGIOUS INTERNATIONAL CANCER
CONFERENCE

CTC HER2 assay being developed for HER2 targeted drugs and antibody drug conjugates
presented at internationally renowned AACR Annual Meeting 2024

GUILDFORD, SURREY / ACCESSWIRE / April 8, 2024 / ANGLE plc (AIM:AG)(OTCQX:ANPCY), a world-leading liquid biopsy company with innovative circulating tumour cell (CTC) solutions for use in research, drug development and clinical oncology, is pleased to announce its participation at the American Association for Cancer Research (AACR) Annual Meeting, San Diego, US between 5 to 10 April 2024.

ANGLE is presenting a poster entitled the "Development and analytical validation of a novel assay for HER2 assessment on circulating tumor cells harvested using the Parsortix system and incorporating BioView imaging technologies". The poster pertains to the Company's collaboration with BioView, for which ANGLE is developing an end-to-end assay for the evaluation of human epidermal growth factor receptor 2 (HER2) gene amplification and protein expression in circulating tumour cells (CTCs) harvested using the Parsortix system from the blood of metastatic breast cancer (MBC) patients. The presented data showcases the development and analytical validation of this assay using the BioView Allegro Plus, an automated, high-throughput platform for imaging and identification of CTCs. The system facilitates the assessment of CTC classification, HER2 biomarker expression, and assessment of HER2 gene copy number by Fluorescence In Situ Hybridization.

ANGLE's in-house study reports the successful identification of the HER2 protein and gene copy information from cell targets with minimal cell loss. The analysis of clinical samples using the assay has demonstrated the ability to detect HER2 positive CTCs in patients who were previously HER2 negative based on a primary tissue biopsy. This assay is being developed as a product kit for minimally invasive identification of HER2 positive and HER2 low patients, who may benefit from HER2-targeted therapies and HER2 antibody-drug conjugates. The ability to monitor HER2 status over time from repeat blood samples may provide valuable data for assessing treatment options. The combination of ANGLE's Parsortix system for harvesting CTCs for analysis, BioView's imaging and analysis technologies, and the new HER2 CTC staining kit under development is intended to provide an easy to use assay based on a simple blood test, providing an up-to-date HER2 status for breast cancer patients on a repeat basis.