Revolution Medicines Presents Promising Clinical Activity and Safety Data from Phase 1/1b Trial of RMC-6236

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REDWOOD CITY, Calif., Oct. 22, 2023 (GLOBE NEWSWIRE) -- Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing targeted therapies for RAS-addicted cancers, today announced promising anti-tumor and safety data for RMC-6236, its RAS^MULTI(ON) Inhibitor, in patients with previously treated non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) across several dose levels and KRAS^G12X genotypes, including common KRAS-mutant genotypes G12D and G12V. These initial results were presented during a Proffered Paper session at the European Society for Medical Oncology (ESMO) Congress in Madrid, October 20-24, 2023.

“Today’s presentation marks an important milestone in the clinical development of RMC-6236, an unprecedented, oral RAS^MULTI(ON) Inhibitor with an innovative mechanism of action. The findings reinforce our belief that by inhibiting the (ON), or active, form of diverse RAS cancer drivers, RMC-6236 can lead to meaningful clinical responses in patients at dose levels that are generally well tolerated,” said Mark A. Goldsmith, M.D., Ph.D., chief executive officer and chairman of Revolution Medicines. “These data also confirm that RMC-6236 can target multiple common RAS variants that cause cancer, supporting its ongoing development as monotherapy in patients with NSCLC or PDAC harboring RAS mutations. Further, RMC-6236 has a compelling profile for evaluation in combination treatment strategies with RMC-6291, our mutant-selective RAS^G12C(ON) Inhibitor, and with immunotherapy and other cancer drugs.”

The RMC-6236-001 Phase 1/1b trial is a multicenter, open-label, dose-escalation and dose-expansion study designed to evaluate RMC-6236 as monotherapy in patients with advanced solid tumors harboring KRAS^G12X mutations. As of an October 12, 2023 data extraction, a total of 111 patients with NSCLC (n=46) or PDAC (n=65) were treated at dose levels administered once daily (QD) ranging from 80 mg to 400 mg. Common KRAS mutations in patients evaluated included G12D, G12V, G12R, G12A and G12S; patients with KRAS^G12C mutations were excluded from the study due to the availability of currently approved KRAS^G12C(OFF) inhibitors. All patients had previously been treated with standard of care appropriate for tumor type and stage. Patients with NSCLC had received a median of two prior lines of therapy (range 1–6) while patients with PDAC had received a median of three prior lines of therapy (range 1–7).