Prelude Announces Multiple Clinical and Preclinical Poster Presentations at AACR-NCI-EORTC International Conference - Seite 2

Preclinical Poster Presentations:

“In addition to the preclinical efficacy we have seen with our potent and selective SMARCA2 degrader, PRT3789, as monotherapy, we see added potential in combination with immunotherapies as well as with chemotherapy and targeted therapies, such as KRAS inhibitors. The sensitive and quantitative assays we have developed to measure SMARCA2 degradation in preclinical models will also enable us to assess target engagement in the clinic. We look forward to the translation of these preclinical results in clinical readouts planned for 2024,” said Peggy Sherle, Ph.D., Chief Scientific Officer of Prelude Therapeutics.

Title: Discovery of PRT3789, a First-in-Class Potent and Selective SMARCA2 Degrader in Clinical Trials for the Treatment of Patients with SMARCA4 Mutated Cancers

Summary:

• PRT3789 is a potent and highly selective SMARCA2 protein degrader that specifically targets SMARCA4-deficient cancer cells.
• In preclinical models, PRT3789 inhibits the growth of SMARCA4-deficient NSCLC tumors as monotherapy and is synergistic in combination with other SOC therapies including chemotherapeutic agents, KRAS G12C inhibitors and anti-PD1 mAb.

Title: Clinical Biomarkers Based on PK/PD Modeling to Guide the Development for a First-in-Class, Highly Selective SMARCA2 (BRM) Degrader, PRT3789

Summary:

• Sensitive and quantitative assays to determine SMARCA2 and SMARCA4 protein levels and changes in SMARCA2-dependent gene expression were developed and will be used to assess selectivity and target engagement following treatment with PRT3789 in the ongoing Phase 1 clinical study.
  

About Prelude Therapeutics

Prelude Therapeutics is a clinical-stage precision oncology company developing innovative drug candidates targeting critical cancer cell pathways. The Company’s diverse pipeline is comprised of highly differentiated, potentially best-in-class proprietary small molecule compounds aimed at addressing clinically validated pathways for cancers with selectable underserved patients. Prelude’s pipeline includes four candidates currently in clinical development: PRT1419, a potent, selective inhibitor of MCL1, PRT2527, a potent and highly selective CDK9 inhibitor, PRT3645 a next generation CDK4/6 inhibitor, and PRT3789 an IV administered, potent and highly selective SMARCA2 degrader, and a preclinical oral candidate targeting SMARCA2.