CalciMedica Announces First Patient Enrolled in International Expansion of CARPO Trial of Auxora in Acute Pancreatitis (AP)

CARPO top-line data expected in 1H2024

CARPO enrolling in over 30 sites in the US and India

LA JOLLA, Calif., Aug. 09, 2023 (GLOBE NEWSWIRE) -- CalciMedica Inc. (“CalciMedica”) (NASDAQ: CALC), a clinical-stage biopharmaceutical company focused on developing novel calcium release-activated calcium (CRAC) channel inhibition therapies for acute and chronic inflammatory and immunologic illnesses, today announced that its ongoing CARPO trial, a Phase 2b trial evaluating Auxora for the treatment of acute pancreatitis (AP) with accompanying systemic inflammatory response syndrome (SIRS), was expanded to clinical research sites in India and that the first patient has been enrolled there.

Overseeing the trial in India as a member of the steering committee is Dr. Pramod Garg, Professor of Gastroenterology and Associate Dean of Research at the All India Institute of Medical Sciences in New Delhi, India.

“We are thrilled to have Dr. Garg overseeing the continuation of our Phase 2b CARPO study in acute pancreatitis in India,” said Sudarshan Hebbar, M.D., Chief Medical Officer of CalciMedica. “Further, we are excited that the study sites in India have significant experience in conducting clinical trials for AP and other critical illnesses. As we move forward with CARPO internationally, we hope to build upon the promising data from our Phase 2a trial of Auxora in patients with AP and accompanying SIRS and the trials in patients with severe or critical COVID-19 pneumonia.”

CARPO is expected to enroll approximately 216 patients at more than 30 sites in the United States and India. The randomized, double-blind, placebo-controlled, dose-ranging trial is intended to demonstrate the tolerability and potential efficacy of Auxora in patients who have AP with accompanying SIRS, a condition that can be life-threatening and for which there is currently no approved therapy. Data from the CARPO trial are expected in the first half of 2024.

“The expansion of CARPO to include international sites is a meaningful achievement in our mission to help patient populations globally whose needs are currently unmet,” said Rachel Leheny, Ph.D., Chief Executive Officer of CalciMedica. “Auxora is a promising therapeutic candidate that has demonstrated in previous clinical trials its strong potential to address the underlying pathobiology of AP and provide a much-needed therapy for these severely ill patients. We look forward to seeing the results from CARPO in the first half of next year.”