Nurix Therapeutics Announces Upcoming Oral Presentation of New Data from Ongoing Clinical Trial of NX-5948, a Selective Bruton’s Tyrosine Kinase (BTK) Degrader, at the European Hematology Association Congress (EHA2024)

Overall response rate of 70% observed in 10 evaluable heavily pretreated CLL patients

Data showcase deepening clinical responses with longer time on therapy in CLL patients including patients with resistance mutations to BTK inhibitors

The oral presentation at EHA will include additional data at higher dose levels and longer treatment durations

Company will host a webcast conference call on June 16 following the data presentation at EHA (details to follow)

SAN FRANCISCO, May 14, 2024 (GLOBE NEWSWIRE) -- Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company developing targeted protein modulation drugs designed to treat patients with cancer and inflammatory diseases, today announced an upcoming oral presentation highlighting new clinical data from Nurix’s orally available, selective BTK degrader, NX-5948, at the European Hematology Association Congress which is being held from June 13 - 16, 2024, in Madrid, Spain, and virtually.

The presentation will summarize updated data from the ongoing Phase 1a/b study of NX-5948 in heavily pretreated patients with relapsed/refractory chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma, including patients with BTK inhibitor resistance mutations and CNS involvement. Among the 10 response-evaluable patients with CLL, the overall response rate at the January 2024 data cutoff was 70%, demonstrating a deepening of responses with longer treatment and follow up. Importantly, all responses remain ongoing as of the January 2024 data cut. Additional data at higher dose levels and longer treatment durations will be presented at EHA2024 in June.

Details of the presentation are as follows:

Title: Latest results from an ongoing first-in-human Phase 1a/b study of NX-5948, a selective Bruton’s tyrosine kinase (BTK) degrader, in patients with relapsed/refractory CLL and other B-cell malignancies.
Session: s445 Novel therapies in relapsed and refractory CLL and hairy cell leukemia
Session Date and Time: Sunday, June 16, 11:30 a.m. – 12:45 p.m. CEST
Location: Hall Velasquez
Presenter: Dr. Kim Linton
Abstract #: S155

Abstracts are available on the EHA2024 website and can be accessed via the Congress website.

About NX-5948

NX-5948 is an investigational, orally bioavailable, small molecule degrader of Bruton’s tyrosine kinase (BTK). NX-5948 is currently being evaluated in a Phase 1 clinical trial in patients with relapsed or refractory B cell malignancies. Nurix has previously reported that NX-5948 is highly potent against a range of tumor cell lines that are resistant to current BTK inhibitor therapies, an important consideration in heavily pretreated CLL/SLL patient populations. Additional information on the ongoing clinical trial can be accessed at clinicaltrials.gov (NCT05131022).