Allurion Announces Three Scientific Presentations at the European Congress on Obesity, Including Study on Lean Mass Preservation for Sustainable, Healthy Weight Loss

Allurion Technologies, Inc. (NYSE: ALUR), a company dedicated to ending obesity, today announced three scientific presentations at the 31^st European Congress on Obesity (ECO) held in Venice, Italy, on 12-15 May, 2024.

Presentations include data from a study of 712 patients treated with the Allurion Program, which is anchored by the Allurion Balloon and enhanced by the Virtual Care Suite featuring Allurion’s proprietary behavior change program. This study was conducted at six obesity centers in six countries, and the data showed patients achieved total body weight loss (TBWL) of 14.1% on average at 4 months, 70% of which came from fat mass and only 30% of which came from lean body mass.

“The Allurion Program was designed to monitor both weight loss and lean body mass, facilitate basic changes in behavior that can protect skeletal muscle, and reduce the impact on lean body mass during periods of rapid weight loss,” said Dr. Shantanu Gaur, Founder and CEO of Allurion. “Research shows that preserving lean body mass while losing weight is critical to maintaining metabolic health and achieving positive, sustained outcomes.”

Existing obesity interventions — including anti-obesity medications such as GLP-1s and bariatric surgery — are often not delivered with coaching or behavior change programs designed to protect lean body mass, which can lead to significant reductions in muscle mass. For example, GLP-1s have been shown to lead to approximately 40% lean body mass loss at one year of treatment.^1,2

“Maintaining lean body mass in the setting of significant caloric deficit is a challenge. We believe the Allurion Program makes this possible with its body composition monitoring and a personalized program that focuses on outcomes beyond just weight,” said Dr. Ram Chuttani, Chief Medical Officer of Allurion. “We will continue to partner with Allurion Program providers to help them optimize their patient outcomes through our training, support, and digital health platform.”

With more intensive programs, early data indicate that muscle mass loss can be avoided entirely. In a previous similar, but smaller, study of a highly intensive multidisciplinary Allurion Program with weekly follow up, patients achieved 14.6% TBWL at 4 months, and their lean body mass actually increased, with 100% of the weight loss derived from fat mass.³

“These results indicate that the Allurion Program may be more protective of muscle mass during weight loss than alternative methods,” continued Gaur. “I am looking forward to exploring how we can leverage the Allurion Virtual Care Suite and Coach Iris to deliver an even more personalized and intensive coaching program to our patients and potentially eliminate muscle mass loss entirely without significant human intervention.”